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Analysen zum transformierenden Potenzial des E4orf3-Proteins von Adenovirus Serotyp 5

URN to cite this document: urn:nbn:de:bvb:355-opus-2060

Täuber, Birgitt (2003) Analysen zum transformierenden Potenzial des E4orf3-Proteins von Adenovirus Serotyp 5. PhD, Universität Regensburg

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Abstract (German)

Die in der vorliegenden Arbeit dargestellten Untersuchungen zum transformierenden Potenzial humaner Adenoviren zeigen erstmals, dass zwei virale Genprodukte der frühen Region 4 - E4orf3 und E4orf6 - von Adenovirus Serotyp 5 transformierende Eigenschaften aufweisen, die zur 'Hit & Run'-Transformation primärer BRK-Zellen beitragen. Den onkogenen Aktivitäten beider E4-Proteine liegen mutagene ...

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Translation of the abstract (English)

The transforming potential of human adenoviruses has been traditionally ascribed to the E1A and E1B transcription units encoded within early region 1 (E1). These gene products are sufficient to initiate complete cell transformation by virtue of their ability to interact with and manipulate the functions of several growth-regulatory proteins that control cell cycle progression and programmed cell ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:11 June 2003
Referee:Charalampos Prof. Dr. Aslanidis
Date of exam:15 May 2002
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Biology, Preclinical Medicine
Keywords:Adenoviren , Transformation , E4orf3 , PML , p300 , 'Hit and Run'-Transformation , E4orf3 , PML , p300 , 'hit and run'-transformation
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Oct 2009 13:07
Last Modified:13 Mar 2014 11:14
Item ID:10097
Owner Only: item control page

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