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Synthese der Alkaloide Botryllazin B und (4-Hydroxyphenyl)-[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanon sowie Synthese von Brevicollinderivaten

URN to cite this document: urn:nbn:de:bvb:355-opus-2467

Lyssenko, Alexei (2004) Synthese der Alkaloide Botryllazin B und (4-Hydroxyphenyl)-[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanon sowie Synthese von Brevicollinderivaten. PhD, Universität Regensburg.

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Abstract (German)

Ziel der vorliegenden Arbeit war die Entwicklung neuer Syntheserouten zur Darstellung von neuen Alkaloiden Botryllazin B (2) und (4-Hydroxyphenyl)-[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanon (3) und deren Derivaten. Als Vorstufe zur Herstellung der beiden Alkaloide verwendeten wir 4-substituierte Oxoacetaldehyde 10-12, die im Falle von (4-Hydroxyphenyl-[6-(4-hydroxyphenyl)pyrazin-2-yl]methanon ...


Translation of the abstract (English)

The pyrazine- and imidazole-derivatives, whose synthesis was studied in the following, contain to a class of natural occurring alkaloids which were first isolated from the red ascidian Botryllus leachi by Duran et al..1 The authors described furthermore some - in particular specific - cytotoxicity against four tumor cell lines. In order to obtain these alkaloids on a synthetic route and to get ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:10 February 2004
Referee:S. (Prof. Dr.) Mahboobi
Date of exam:15 April 2003
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Keywords:Organische Synthese , Asymmetrische Synthese , Chemische Synthese , Arzneimittel / Chemische Synthese , Alkaloide , Ibogaalkaloide , Pyrrolimidazolalkaloide , Brevicollin , Brevicollin-derivate , Botryllazin B , Imidazol-derivate , Pyrazine- and imidazole-alkaloids , annular tautomers , Botryllus laechi , biologically active compounds
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:26 Oct 2009 15:33
Last modified:13 Mar 2014 11:20
Item ID:10172
Owner only: item control page


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