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Gene therapy for muscular dystrophy using secondary modifiers of the dystrophic phenotype

URN to cite this document: urn:nbn:de:bvb:355-opus-4086

Abmayr, Simone (2005) Gene therapy for muscular dystrophy using secondary modifiers of the dystrophic phenotype. PhD, Universität Regensburg

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Abstract (English)

The absence of dystrophin in Duchenne muscular dystrophy causes sarcolemmal instability and renders muscle fibers susceptible to contraction-induced injury. Muscle repair mechanisms cannot compensate for progressive muscle degeneration, leading to a gradual replacement of muscle with adipose and connective tissue. Viral vectors have been successfully used to deliver dystrophin cDNA to ...

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Translation of the abstract (German)

Das Fehlen von Dystrophin in Muskeldystrophie Duchenne führt zur Instabilität von Muskelmembranen, die somit leicht durch Muskelkontraktionen beschädigt werden können. Zusätzlich führen eine Beeinträchtigung wesentlicher Mechanismen der Signaltransduktion, sowie unzureichende Muskelregeneration, zu einem fortschreitenden Verlust des Muskelgewebes, das dadurch nach und nach von Binde-und ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:13 January 2005
Referee:Jeffrey (Prof. Dr.) Chamberlain
Date of exam:30 July 2004
Institutions:Biology, Preclinical Medicine
Keywords:Gentherapie , Muskeldystrophie , Duchenne-Syndrom , , Gene therapy , Duchenne muscular dystrophy
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 06:49
Last Modified:13 Mar 2014 11:26
Item ID:10266
Owner Only: item control page

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