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Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro

Blank, Christian and Kuball, Juergen and Voelkl, Simon and Wiendl, Heinz and Becker, Bernd and Walter, Bernhard and Majdic, Otto and Gajewski, Thomas F and Theobald, Mathias and Andreesen, Reinhard and Mackensen, Andreas (2006) Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. International journal of cancer. Journal international du cancer 119 (2), pp. 317-327.

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Other URL: http://dx.doi.org/10.1002/ijc.21775


Abstract

Human tumors frequently escape immune destruction, despite the presence of cytotoxic T cells (CTL) recognizing tumor-associated antigens (TAA). We have previously shown that programmed death ligand-1 (PD-L1), a recently identified ligand of the B7 superfamily, is expressed on murine tumors and can inhibit antitumor immune responses. To evaluate the clinical relevance of our animal model findings, ...

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Item Type:Article
Date:15 July 2006
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
16482562PubMed ID
10.1002/ijc.21775DOI
Keywords:RCC; PD-L1; PD-1; B7-H1; melanoma
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Feb 2007
Last Modified:13 Mar 2014 09:44
Item ID:1031
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