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Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy

URN to cite this document: urn:nbn:de:bvb:355-opus-5194

Hoechstetter, Julia (2005) Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy. PhD, Universität Regensburg

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Abstract (English)

Pharmaceutical preparations of bovine testicular hyaluronidase (BTH) have been therapeutically applied in several medical fields for many years. In the context with the risk of BSE, companies stopped the production of BTH preparations resulting in a shortage of this drug, which is the only highly effective antidote in the treatment of extravasations of vinca alkaloids. To find a substitute for ...

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Translation of the abstract (German)

Arzneimittel mit boviner testikulärer Hyaluronidase (BTH) als wirksamer Bestandteil wurden therapeutisch erfolgreich eingesetzt. Wegen der TSE-Problematik wurde die Produktion dieser Medikamente eingestellt, so dass es, trotz großer Nachfrage, insbesondere als hochwirksames Antidot bei Paravasaten (Vincaalkaloide), zu einem Engpass an BTH-Präparaten kam. Obwohl BTH-Präparate in der Klinik lange ...

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Export bibliographical data



Item Type:Thesis of the University of Regensburg (PhD)
Date:1 August 2005
Referee:Prof. Dr. Armin Buschauer
Date of exam:30 March 2005
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Hyaluronidasen , Enzymologie , pH-Profile , spreading factor , Hyaluronsäure-Analytik , hyaluronidases , enzymology , pH profiles , spreading factor , hyaluronan analytics
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 07:00
Last Modified:13 Mar 2014 11:29
Item ID:10330
Owner Only: item control page

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