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Synthesis and immobilisation of biologically active substances

URN to cite this document: urn:nbn:de:bvb:355-opus-5004

Walenzyk, Thomas (2006) Synthesis and immobilisation of biologically active substances. PhD, Universität Regensburg

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Abstract (English)

Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 10E4 fold enhanced intrinsic reactivity for the hydrolysis of phosphodiesters over the non-catalysed reaction in ...

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Translation of the abstract (German)

Viele natürliche Hydrolasen haben Zn(II) in ihrem aktiven Zentrum. Künstliche Hydrolasen, die als Alternativen für nicht-enzymatische Hydrolysen verwendet werden, bestehen oft aus festphasen-gebundenem Zn(II)-Cyclen. Studien mit diesem System zeigten eine 10E4-fache Beschleunigung der Hydrolyse-Geschwindigkeit von Phosphorsäurediestern im Vergleich zu nicht katalysierten Reaktionen in Lösung. ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:17 May 2006
Referee:Burkhard (Prof. Dr.) König
Date of exam:24 March 2005
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:Chromone , Zinkkomplexe , bioaktive Verbindungen , Chemische Synthese , Cyclische Verbindungen , Immobilisierung , Chromophore , organische-anorganische Hybride , UV-Filter , immobilisation , chromophore , organic-inorganic hybrids , chromone , UV filter
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 07:38
Last Modified:13 Mar 2014 11:33
Item ID:10377
Owner Only: item control page

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