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Isolation of CD4+CD25+ regulatory T cells for clinical trials

Hoffmann, Petra and Boeld, Tina J. and Eder, Ruediger and Albrecht, Julia and Doser, Kristina and Piseshka, Biserka and Dada, Ashraf and Niemand, Claudia and Assenmacher, Mario and Orsó, Evelyn and Andreesen, Reinhard and Holler, Ernst and Edinger, Matthias (2006) Isolation of CD4+CD25+ regulatory T cells for clinical trials. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 12 (3), pp. 267-274.

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Other URL: http://dx.doi.org/10.1016/j.bbmt.2006.01.005


The adoptive transfer of donor CD4+CD25+ regulatory T cells has been shown to protect from lethal graft-versus-host disease after allogeneic bone marrow transplantation in murine disease models. Efficient isolation strategies that comply with good manufacturing practice (GMP) guidelines are prerequisites for the clinical application of human CD4+CD25+ regulatory T cells. Here we describe the ...


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Item Type:Article
Date:March 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
16503495PubMed ID
Keywords:Anergy; Tolerance; Suppressor T lymphocytes; Graft-versus-host disease; Good manufacturing practice
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Deposited On:08 Feb 2007
Last Modified:20 Apr 2010 08:51
Item ID:1039
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