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Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors

URN to cite this document: urn:nbn:de:bvb:355-opus-6792

Ziemek, Ralf (2006) Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors. PhD, Universität Regensburg

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Abstract (English)

For the discovery and pharmacological characterization of new ligands of G-protein coupled receptors, simple, robust and reliable assays are required. This thesis was aimed at the development of new binding and functional assays for the neuropeptide Y (NPY) receptor subtypes hY2, hY4 and rY4. CHO cells were stably transfected with the hY2 receptor gene and used in a flow cytometric binding ...

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Translation of the abstract (German)

Für die Entdeckung und pharmakologische Charakterisierung neuer Liganden für G-Protein gekoppelte Rezeptoren werden einfache, robuste und zuverlässige Testsysteme benötigt. Ziel dieser Arbeit war die Entwicklung neuer Bindungs- und funktioneller Assays für die Neuropeptid Y (NPY) Rezeptoren hY2, hY4 und rY4. Zunächst wurden CHO Zellen stabil mit dem hY2 Rezeptorgen transfiziert und in einem ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:2 August 2006
Referee:Prof. Dr. Armin Buschauer
Date of exam:26 May 2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Neuropeptid Y , Nachweis , Durchflusscytometrie , Aequorin , Rezeptor , Neuropeptid Y , pharmakologische Assays , Durchflusszytometrie , Aequorin , neuropeptide Y , assays , flow cytometry , aequorin
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 07:48
Last Modified:13 Mar 2014 11:39
Item ID:10449
Owner Only: item control page

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