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Polyethylenimine-derived gene carriers and their complexes with plasmid DNA. Design, synthesis and characterization

URN to cite this document: urn:nbn:de:bvb:355-opus-7445

Lungwitz, Uta (2006) Polyethylenimine-derived gene carriers and their complexes with plasmid DNA. Design, synthesis and characterization. PhD, Universität Regensburg.

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Abstract (English)

In recent years viral as well as non-viral gene transfer emerged as a promising technique in molecular medicine as well as in basic research. Branched polyethylenimine (bPEI) has been introduced as a synthetic non- viral gene carrier. Unfortunately, its applicability is still limited by a low transfection efficacy and eminent cytotoxicity. The goal of this thesis was the design, synthesis and ...


Translation of the abstract (German)

Der Transfer von Genen wurde in den letzten Jahren zu einer wichtigen Arbeitstechnik in der Forschung und mag zukünftig auch als Therapiekonzept Anwendung finden. 1995 wurde das verzweigte Polyethylenimin (PEI) als vielversprechender nicht-viraler Genträger eingeführt. Aufgrund der niedrigen Transfektionseffizienz und eminenten Zytotoxizität findet jedoch bisher noch keine breite Anwendung. ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:14 December 2006
Referee:Achim (Prof. Dr.) Göpferich
Date of exam:10 August 2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:DNS , Gentransfer , Polyethylenimin , Nanopartikel , Transfektion , Plasmid , , DNA , gene transfer , polyethylenimine , nanoparticle , transfection
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:27 Oct 2009 07:52
Last modified:13 Mar 2014 11:41
Item ID:10486
Owner only: item control page


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