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New guanidinium compounds for the molecular recognition of carboxylates and contributions to the synthesis of bivalent NPY Y1 receptor antagonists

URN to cite this document: urn:nbn:de:bvb:355-opus-6428

Suhs, Thomas (2007) New guanidinium compounds for the molecular recognition of carboxylates and contributions to the synthesis of bivalent NPY Y1 receptor antagonists. PhD, Universität Regensburg

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Abstract (English)

The chemical properties of the guanidinium group as well as its ability to form H-bonds, charge pairing and cation-π interactions opens up a large number of possibilities in molecular recognition and pharmaceutical chemistry. In the first chapter, the synthesis of Artificial Ethoxycarbonyl Guanidinium Amino Acids is reported. Carboxy� and amino-groups can be selectively deprotected, but ...

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Translation of the abstract (German)

Im ersten Kapitel der Arbeit wird die Synthese von Ethoxycarbonyl Guanidinium Aminosäuren beschrieben. Carboxy- und Aminoende können durch geeignete Methoden weiter funktionalisiert werden. Die Ethoxycarbonylgruppe kann enzymatisch mittels einer Esterase (E.C. 3.1.1.1) abgespalten werden. Die Bindungseigenschaften gegenüber Carboxylaten wurden mittels NMR-Titrationen untersucht. In weiteren ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:5 March 2007
Referee:Burkhard (Prof. Dr.) König
Date of exam:24 March 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:Molekulare Erkennung , Neuropeptid Y , Carboxylate , Supramolekulare Chemie , Fluoreszenzspektroskopie , Guanidiniumverbindungen , Carbonylverbindungen , Ethoxygruppe , Chemische Synthese , Chemische Bindung , NMR-Spektroskopie , Titration , Fluorophore , , Molecular recognition , Guanidines , NPY Y1 antagonists , fluorescence titrations , synthesis of guanidines
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 08:10
Last Modified:13 Mar 2014 11:43
Item ID:10492
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