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Accurate proton-proton distance calculation and error estimation from NMR data for automated protein structure determination in AUREMOL

URN to cite this document: urn:nbn:de:bvb:355-opus-6491

Trenner, Jochen Markus (2007) Accurate proton-proton distance calculation and error estimation from NMR data for automated protein structure determination in AUREMOL. PhD, Universität Regensburg

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Abstract (English)

In this dissertation the development of the NMR spectrum analysis program AUREMOL is continued, which aims at the full automation of protein structure determination. The present threshold based peak picking routine is enhanced to adapt the threshold locally based on a local noise estimate and the segmentation based integration routine in AUREMOL is extended to produce an error estimate for every ...

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Translation of the abstract (German)

In dieser Dissertation wird die Entwicklung des NMR-Auswerteprogramms AUREMOL weitergeführt, das die vollständige Automatisierung der Proteinstrukturbestimmung zum Ziel hat. Die bestehende schwellwertbasierte Signalidentifikation wird dahingehend erweitert, daß auf der Basis einer lokalen Rauschniveau-Abschätzung ein adaptiver Schwellwert verwendet wird. Die Segmentierungsroutine für die ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:25 April 2007
Referee:Hans Robert (Prof. Dr. Dr.) Kalbitzer
Date of exam:4 April 2006
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Classification:
NotationType
87.15.-vPACS
87.15.AaPACS
Keywords:Magnetische Kernresonanz , NOESY , Proteine , Tertiärstruktur , Strukturanalyse , Mehrdimensionale NMR-Spektroskopie , Computerunterstütztes Verfahren , NMR , AUREMOL , REFINE , RELAX , Struktur , AUREMOL , protein structure , refinement , restraint
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 08:10
Last Modified:13 Mar 2014 11:43
Item ID:10496
Owner Only: item control page
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