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Asymmetric methodologies for the construction of 5,7,5- and 6,6,6-tricyclic sesquiterpene lactones towards the synthesis of Arglabin

URN to cite this document: urn:nbn:de:bvb:355-opus-6860

Jeong, Won Boo (2007) Asymmetric methodologies for the construction of 5,7,5- and 6,6,6-tricyclic sesquiterpene lactones towards the synthesis of Arglabin. PhD, Universität Regensburg

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Abstract (English)

Many naturally extracted guaianolides (i.e. GLs) and pseudoguaianolides are based on the 5,7,5-fused ring skeleton and they show a broad biological profile. Among them, Arglabin has attracted special attention due to its promising antitumor and cytotoxic activity as an inhibitor of Farnesyltransferase. In the present work the asymmetric synthesis towards Arglabin was investigated via ...

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Translation of the abstract (German)

Viele der identifizierten Naturstoffe der Guaianolide (GLs) und Pseudoguaianolide basieren auf 5,7,5-verknüpften Ring-Systemen und zeigen ein breites biologisches Wirkungsprofil. Des Weiteren ist Arglabin wegen seiner antitumor und cytotoxischen Aktivität als Farnesyltransferase Inhibitor interessant. In der vorliegenden Arbeit wurde die Synthese von Arglabin über ein ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:5 August 2007
Referee:Oliver (Prof. Dr.) Reiser
Date of exam:14 July 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Asymmetrische Synthese , Guaianolide , Arglabin , Sesquiterpenlactone , Tricyclische Verbindungen , , asymmetric synthesis , guaianolide , Arglabin
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 08:11
Last Modified:13 Mar 2014 11:44
Item ID:10508
Owner Only: item control page
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