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Recombinant expression, purification and characterization of human hyaluronidases

URN to cite this document: urn:nbn:de:bvb:355-opus-7884

Hofinger, Edith (2007) Recombinant expression, purification and characterization of human hyaluronidases. PhD, Universität Regensburg

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Abstract (English)

Hyaluronidases and their substrate, hyaluronic acid, are known to play a role in signal transduction events directly correlated with tumor growth and cell migration. Yet correlations with disease progression are controversial due to scarce information on enzymatic properties and the lack of specific inhibitors as pharmacological tools. Therefore, the aim of this thesis was the establishment of ...


Translation of the abstract (German)

Hyaluronsäure und Hyaluronidasen spielen bei Signaltransduktionsprozessen eine Rolle, die mit der Zellmigration und dem Wachstum von Tumoren korrelieren. Allerdings liegen nur unzureichende Informationen über die enzymatischen Eigenschaften der Hyaluronidasen vor und es existieren keine geeigneten Inhibitoren als pharmakologische Werkzeuge. Daher war das Ziel dieser Arbeit die rekombinante ...


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Item Type:Thesis of the University of Regensburg (PhD)
Date:9 May 2007
Referee:Prof. Dr. Armin Buschauer
Date of exam:30 March 2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Hyaluronidasen , Hyaluronsäure , Rekombinantes Protein , Einschlusskörper , Kapillarelektrophorese , Proteinfaltung , Isolierung <Chemie> , Drosophila Schneider-2 Zellen , Proteinreinigung , Glykosylierung , hyaluronidase , hyaluronic acid , recombinant protein , protein purification
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:27 Oct 2009 11:54
Last Modified:13 Mar 2014 11:46
Item ID:10549
Owner Only: item control page


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