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The H-Bonding Network of Acylguanidine Complexes: Combined Intermolecular 2hJH,P and 3hJN,P Scalar Couplings Provide an Insight into the Geometric Arrangement

Federwisch, G. and Kleinmaier, R. and Drettwan, D. and Gschwind, R. M. (2008) The H-Bonding Network of Acylguanidine Complexes: Combined Intermolecular 2hJH,P and 3hJN,P Scalar Couplings Provide an Insight into the Geometric Arrangement. Journal of the American Chemical Society 130 (50), pp. 16846-16847.

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Abstract

The H-bonding networks of arginines and acylguanidines are crucial for many biological and pharmaceutical interactions. However, the effect of acylation of guanidines on the binding mode and the H-bond strengths has not yet been explored in solution. Therefore, the H-bonding network of a 15N labeled acylguanidine derivative in a bisphosphonate arginine receptor is investigated. The direct NMR ...

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Item Type:Article
Date:2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1021/ja807042uDOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Nikola Kastner-Pustet
Deposited On:11 Nov 2009 15:32
Last Modified:11 Nov 2009 15:32
Item ID:10624
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