Zhang, H. and Gschwind, R. M. (2007) Influence of Copper Salts, Solvents, and Ligands on the Structures of Precatalytic Phosphoramidite Copper Complexes for Conjugate Addition Reactions. Chemistry - A European Journal 13 (23), pp. 6691-6700.
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For copper-catalyzed enantioselective conjugate addition reactions of organozinc reagents, the available knowledge about the mechanism and the structures involved is still insufficient to understand in detail the strong influences of solvent, salt, and ligand size, or to enable a rational control of this reaction. Screening with three phosphoramidite ligands and four copper(I) salts using NMR spectroscopy has revealed a binuclear copper complex with mixed trigonal/tetrahedral stereochemistry as the basic structural motif of the ground state of precatalysts with highly stereoselective ligands. Ligands with smaller amine moieties allow higher coordination numbers and higher aggregation levels, leading to reduced ee values. Since the ESI mass spectra of several precatalytic copper halide complexes show a striking correlation with the structures observed in solution, ESI-MS may be used as a fast tool to determine the maximum number of phosphoramidite ligands attached to copper.
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind|
|Keywords:||asymmetric catalysis; conjugate addition; copper; NMR spectroscopy; phosphoramidite ligands|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||11 Nov 2009 17:17|
|Last Modified:||11 Nov 2009 17:17|
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