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Identification of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gamma delta T cells in Escherichia coli

Hintz, M. and Reichenberg, A. and Altincicek, B. and Bahr, U. and Gschwind, R. M. and Kollas, A. and Beck, E. and Wiesner, J. and Eberl, M. and Jomaa, H. (2001) Identification of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gamma delta T cells in Escherichia coli. FEBS Letters 509 (2), pp. 317-322.

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Abstract

The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-Image -erythritol 4-phosphate pathway in Escherichia coli. In lytB-deficient mutants, a highly immunogenic compound accumulates significantly, compared to wild-type E. coli, but is apparently absent in gcpE-deficient mutants. Here, this compound was purified from E. coli ΔlytB mutants by ...

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Item Type:Article
Date:2001
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind
Identification Number:
ValueType
10.1016/S0014-5793(01)03191-X DOI
Keywords:γδ T cell; 2-C-Methyl-Image -erythritol 4-phosphate pathway; 4-Hydroxy-3-methyl-but-2-enyl pyrophosphate; gcpE; lytB
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Nikola Kastner-Pustet
Deposited On:11 Nov 2009 17:12
Last Modified:11 Nov 2009 17:12
Item ID:10647
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