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Control of epithelial Na+ channels by CFTR, receptors and kinases

URN to cite this document: urn:nbn:de:bvb:355-opus-9228

Bachhuber, Tanja (2008) Control of epithelial Na+ channels by CFTR, receptors and kinases. PhD, Universität Regensburg

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Abstract (English)

The epithelial Na+ channel (ENaC) is located in the apical membrane of salt (re-) absorbing epithelia in kidney, colon, airways and glandular excretory ducts. In this thesis it is demonstrated that both stimulation of purinergic receptors and activation of the cystic fibrosis transmembrane conductance regulator (CFTR) and other Cl- channels lead to inhibition of epithelial Na+ channels, ...

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Translation of the abstract (German)

Der epitheliale Na+-Kanal (ENaC) wird in der apikalen Membran von Kochsalz-(re-) absorbierenden Epithelien in Niere, Kolon, Luftwegen und exkretorischen Drüsen exprimiert. In dieser Arbeit wird gezeigt, dass sowohl die Stimulation purinerger Rezeptoren als auch die Aktivierung des cystic fibrosis transmembrane conductance regulator (CFTR) und anderer Cl--Kanäle die Hemmung epithelialer ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:29 January 2008
Referee:Karl (Prof. Dr.) Kunzelmann
Date of exam:29 November 2007
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann
Keywords:Natriumkanal , Chloridkanal , Purinozeptor , Mukoviszidose , Regulation , Proteinkinase CK2 , ENaC , CFTR , Protein-Kinase CK2 , Regulation von ENaC , ENaC , CFTR , protein kinase CK2 , regulation of ENaC
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 16:19
Last Modified:13 Mar 2014 11:52
Item ID:10701
Owner Only: item control page

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