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Chorismate mutase of Thermus thermophilus is a monofunctional AroH class enzyme inhibited by tyrosine

Helmstaedt, Kerstin and Heinrich, Gabriele and Merkl, Rainer and Braus, Gerhard H. (2004) Chorismate mutase of Thermus thermophilus is a monofunctional AroH class enzyme inhibited by tyrosine. Archives of Microbiology 181 (3), pp. 195-203.

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aroG, encoding the monofunctional chorismate mutase (TtCM) of the thermophilic gram-negative bacterium Thermus thermophilus, was cloned and its gene product characterized. TtCM was purified to homogeneity on an SDS polyacrylamide gel as a His-fusion protein with a deduced molecular mass of 15.8 kDa. The enzyme belongs to the rare group of AroH-type chorismate mutases which are mainly found in ...


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Item Type:Article
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Identification Number:
14727008PubMed ID
Amino Acid SequenceMESH
Chorismate Mutase/antagonists & inhibitorsMESH
Chorismate Mutase/chemistryMESH
Chorismate Mutase/geneticsMESH
Chorismate Mutase/metabolism*MESH
Cloning, MolecularMESH
DNA, Bacterial/chemistryMESH
DNA, Bacterial/isolation & purificationMESH
Enzyme Inhibitors/pharmacologyMESH
Enzyme StabilityMESH
Genes, BacterialMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Molecular WeightMESH
Protein ConformationMESH
Protein Subunits/physiologyMESH
Recombinant Proteins/metabolismMESH
Sequence AlignmentMESH
Sequence Analysis, DNAMESH
Sequence Homology, Amino AcidMESH
Thermus thermophilus/enzymology*MESH
Thermus thermophilus/genetics*MESH
Keywords:Amino Acid Sequence Chorismate Mutase/antagonists & inhibitors/chemistry/genetics/*metabolism Cloning, Molecular DNA, Bacterial/chemistry/isolation & purification Enzyme Inhibitors/pharmacology Enzyme Stability Genes, Bacterial Kinetics Models, Molecular Molecular Sequence Data Molecular Weight Phylogeny Protein Conformation Protein Subunits/physiology Recombinant Proteins/metabolism Research Support, Non-U.S. Gov't Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Thermus thermophilus/*enzymology/*genetics Tyrosine/*pharmacology
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Deposited On:13 Nov 2009 13:25
Last Modified:21 Dec 2009 07:46
Item ID:10913
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