Henne, Anke and Brüggemann, Holger and Raasch, Carsten and Wiezer, Arnim and Hartsch, Thomas and Liesegang, Heiko and Johann, Andre and Lienard, Tanja and Gohl, Olivia and Martinez-Arias, Rosa and Jacobi, Carsten and Starkuviene, Vytaute and Schlenczeck, Silke and Dencker, Silke and Huber, Robert and Klenk, Hans Peter and Kramer, Wilfried and Merkl, Rainer and Gottschalk, Gerhard and Fritz, Hans Joachim (2004) The genome sequence of the extreme thermophile Thermus thermophilus. Nature Biotechnology 22 (5), pp. 547-553.
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Thermus thermophilus HB27 is an extremely thermophilic, halotolerant bacterium, which was originally isolated from a natural thermal environment in Japan. This organism has considerable biotechnological potential; many thermostable proteins isolated from members of the genus Thermus are indispensable in research and in industrial applications. We present here the complete genome sequence of T. thermophilus HB27, the first for the genus Thermus. The genome consists of a 1,894,877 base pair chromosome and a 232,605 base pair megaplasmid, designated pTT27. The 2,218 identified putative genes were compared to those of the closest relative sequenced so far, the mesophilic bacterium Deinococcus radiodurans. Both organisms share a similar set of proteins, although their genomes lack extensive synteny. Many new genes of potential interest for biotechnological applications were found in T. thermophilus HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation.
|Institutions:||Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner > Arbeitsgruppe PD Dr. Rainer Merkl|
|Subjects:||500 Science > 570 Life sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||13 Nov 2009 14:06|
|Last Modified:||21 Dec 2009 08:46|
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