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Induction of Raf kinase inhibitor protein contributes to macrophage differentiation

Schuierer, Marion M. and Heilmeier, Ursula and Boettcher, Alfred and Ugocsai, Peter and Bosserhoff, Anja K. and Schmitz, Gerd and Langmann, Thomas (2006) Induction of Raf kinase inhibitor protein contributes to macrophage differentiation. Biochemical and biophysical research communications 342 (4), pp. 1083-1087.

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Other URL: http://dx.doi.org/10.1016/j.bbrc.2006.02.083


Abstract

Differential gene expression analysis of human blood monocytes has identified the Raf kinase inhibitor protein (RKIP) as a continuously upregulated gene in macrophage and dendritic cell maturation. Using realtime RT-PCR and Western blot analysis we were able to confirm the initial DNA-microarray findings of RKIP induction on mRNA and protein levels. RKIP upregulation in primary cells and ...

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Item Type:Article
Date:21 April 2006
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
ValueType
16513087PubMed ID
10.1016/j.bbrc.2006.02.083DOI
Keywords:Gene expression; Raf kinase inhibitor protein; Macrophage differentiation; NFκB; Scavenger receptors; THP-1 cells
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Ute Lange
Deposited On:01 Mar 2007
Last Modified:13 Mar 2014 09:45
Item ID:1099
Owner Only: item control page

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