Startseite UB

p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes

Radons, Jürgen and Bosserhoff, Anja Katrin and Grässel, Susanne and Falk, Werner and Schubert, Thomas E. O. (2006) p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. International journal of molecular medicine 17 (4), pp. 661-668.

[img]PDF
Download (177kB) - Repository staff only

at PubMed

Other URL: http://147.52.72.117/IJMM/ijmm.htm


Abstract

The pleiotropic cytokine interleukin 1 (IL-1) is considered to be the principal inducer of mediators of cartilage degradation in both, osteoarthritis (OA) and rheumatoid arthritis (RA). IL-1 activates numerous signaling pathways involved in cartilage destruction and dedifferentiation of chondrocytes. In this study, we analyzed expression and functional effects of IL-1 in human chondrocytes. We ...

plus


Export bibliographical data



Item Type:Article
Date:April 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
16525725PubMed ID
Keywords:chondrocytes; IL-1, IL-6; p38MAPK; signal transduction; aggrecan; PI3K, JNK, ERK1/2
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Ute Lange
Deposited On:02 Mar 2007
Last Modified:13 Mar 2014 09:45
Item ID:1102
Owner Only: item control page

Downloads

Downloads per month over past year

  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact