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Synthesis of a biotinated amphiphile

Amslinger, S. and Hirsch, A. and Hampel, F. (2004) Synthesis of a biotinated amphiphile. Tetrahedron 60 (50), pp. 11565-11569.

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Abstract

The synthesis of a biotinated amphiphile assembled from D-(+)-biotin, ethylene diamine as spacer, galactaric acid and 1-dodecylamine was achieved in six steps. The key step was the synthesis of a bisacetonide protected galactaric ester, the structure of which was determined by X-ray analysis. Aminolysis, spacer attachment, coupling with biotin and deprotection led to the amphiphilic ...

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Item Type:Article
Date:2004
Additional information (public):Times Cited: 0
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
ISI:000225148000028Web of Science ID
10.1016/j.tet.2004.09.063 DOI
Keywords:D-(+)-biotin amphiphile galactaric acid carbohydrate derivatives Derivatives nmr
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Dr. Sabine Amslinger
Deposited On:24 Nov 2009 15:02
Last Modified:07 Nov 2012 11:11
Item ID:11063
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