Amslinger, S. and Kis, K. and Hecht, S. and Adam, P. and Rohdich, F. and Arigoni, D. and Bacher, A. and Eisenreich, W. (2002) Biosynthesis of terpenes. Preparation of (E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway. The Journal of Organic Chemistry 67 (13), pp. 4590-4594.
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(E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate (E-6) was synthesized in six reaction steps from hydroxyacetone (9) and (ethoxycarbonylmethenyl)-triphenylphosphorane (11) with an overall yield of 38%. The compound was shown to be identical with the product of IspG protein, which serves as an intermediate in the nonmevalonate terpene biosynthetic pathway.
|Additional information (public):||Times Cited: 10|
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger|
|Keywords:||2-c-methyl-d-erythritol 4-phosphate pathway escherichia-coli isoprenoid biosynthesis nonmevalonate pathway 4-(cytidine 5'-diphospho)-2-c-methyl-d-erythritol isopentenyl diphosphate gene 5-phosphate protein lytb|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Dr. Sabine Amslinger|
|Deposited On:||24 Nov 2009 15:24|
|Last Modified:||12 Nov 2012 13:52|