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Studies on the non-mevalonate isoprenoid biosynthetic pathway. Simple methods for preparation of isotope-labeled (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate

Hecht, S. and Amslinger, S. and Jauch, J. and Kis, K. and Trentinaglia, V. and Adam, P. and Eisenreich, W. and Bacher, A. and Rohdich, F. (2002) Studies on the non-mevalonate isoprenoid biosynthetic pathway. Simple methods for preparation of isotope-labeled (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. Tetrahedron Lett. 43 (49), pp. 8929-8933.

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Abstract

(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-H-3]-6 and [1-H-2(1)]-6 from the same starting material in four steps where the hydrogen isotope is ...

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Item Type:Article
Date:2002
Additional information (public):Times Cited: 10
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
ISI:000179238400030Web of Science ID
10.1016/S0040-4039(02)02195-0 DOI
Keywords:Escherichia-coli precursor thiamin d-1-deoxyxylulose 5-phosphate pyridoxol thiazole
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Dr. Sabine Amslinger
Deposited On:24 Nov 2009 14:43
Last Modified:12 Nov 2012 13:54
Item ID:11073
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