Dummer, Reinhard and Posseckert, Gerhard and Nestle, Frank and Witzgall, Ralph and Burger, Mathias and Becker, Jürgen C. and Schäfer, Erwin and Wiede, Johannes and Sebald, Walter and Burg, Günter
Soluble Interleukin-2 Receptors Inhibit Interleukin 2-Dependent Proliferation and Cytotoxicity: Explanation for Diminished Natural Killer Cell Activity in Cutaneous T-Cell Lymphomas In Vivo?
Journal of Investigative Dermatology 98 (1), pp. 50-54.
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In patients with cutaneous T-cell lymphomas (CTCL), soluble interleukin-2 receptor serum levels (sIL-2R) were determined by ELISA technique, and natural killer cell (NK) activity, by a 4-h chromium-51 release assay. Decrease of NK activity correlated with the augmentation of serum sIL-2R. After a 4-d stimulation with interleukin 2 CTCL patients' peripheral mononuclear cells (PMC) showed an ...
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