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Soluble Interleukin-2 Receptors Inhibit Interleukin 2-Dependent Proliferation and Cytotoxicity: Explanation for Diminished Natural Killer Cell Activity in Cutaneous T-Cell Lymphomas In Vivo?

Dummer, Reinhard and Posseckert, Gerhard and Nestle, Frank and Witzgall, Ralph and Burger, Mathias and Becker, Jürgen C. and Schäfer, Erwin and Wiede, Johannes and Sebald, Walter and Burg, Günter (1992) Soluble Interleukin-2 Receptors Inhibit Interleukin 2-Dependent Proliferation and Cytotoxicity: Explanation for Diminished Natural Killer Cell Activity in Cutaneous T-Cell Lymphomas In Vivo? Journal of Investigative Dermatology 98 (1), pp. 50-54.

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Abstract

In patients with cutaneous T-cell lymphomas (CTCL), soluble interleukin-2 receptor serum levels (sIL-2R) were determined by ELISA technique, and natural killer cell (NK) activity, by a 4-h chromium-51 release assay. Decrease of NK activity correlated with the augmentation of serum sIL-2R. After a 4-d stimulation with interleukin 2 CTCL patients' peripheral mononuclear cells (PMC) showed an ...

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Item Type:Article
Date:1992
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und Zelluläre Anatomie > Prof. Dr. Ralph Witzgall
Identification Number:
ValueType
10.1111/1523-1747.ep12494223DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Universitätsbibliothek Regensburg
Deposited On:06 Dec 2010 09:14
Last Modified:13 Mar 2014 14:14
Item ID:11206
Owner Only: item control page

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