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Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Ljubimova, J. Y. and Fujita, M and Lee, B. S. and Khazenzon, N. M. and Wachsmann-Hogiu, S. and Farkas, D. L. and Black, K. L. and Holler, E, (2006) Nanoconjugates of poly(malic acid) with functional modules for drug delivery. In: Nanotech 2006. Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show. Volume 2. Nano Science and Technology Institute, Cambridge, Massachusetts, pp. 354-357. ISBN 0-9767985-7-3.

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Abstract

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold ...

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Item Type:Book Section
Date:2006
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Keywords:antisense oligonucleotides; antibodies; tissue targeting; fluorescence imaging; tumor angiogenesis
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:12 Jul 2006
Last Modified:05 Aug 2009 13:21
Item ID:115
Owner Only: item control page
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