Ehling, Angela and Schäffler, Andreas and Herfarth, Hans and Tarner, Ingo H. and Anders, Sven and Distler, Oliver and Paul, Gisela and Distler, Jörg and Gay, Steffen and Schölmerich, Jürgen and Neumann, Elena and Müller-Ladner, Ulf (2006) The potential of adiponectin in driving arthritis. Journal of immunology 176 (7), pp. 4468-4478.
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Articular adipose tissue is a ubiquitous component of human joints, but its local functions are largely unknown. Because recent studies revealed several links between adipose tissue, adipocytokines, and arthritis, we investigated the expression of the adipocytokine adiponectin and its functional role in articular adipose tissue and synovium of patients with different arthritides. In contrast to its protective role in endocrinological and vascular diseases, adiponectin was found to be involved in key pathways of inflammation and matrix degradation in the human joint. The effects of adiponectin in human synovial fibroblasts appear to be highly selective by inducing only two of the main mediators of rheumatoid arthritis pathophysiology, IL-6 and matrix metalloproteinase-1, via the p38 MAPK pathway. Owing to the observation that these effects could be inhibited by different TNF-alpha inhibitors, adipocytokines such as adiponectin may also be key targets for therapeutic strategies in inflammatory joint diseases. In summary, articular adipose tissue and adipocytokines cannot be regarded as innocent bystanders any more in chronic inflammatory diseases such as arthritis.
|Date:||1 April 2006|
|Institutions:||Medicine > Lehrstuhl für Innere Medizin I|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||15 Mar 2007|
|Last Modified:||20 Jul 2011 20:52|