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Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor

Gamulescu, Maria-Andreea and Chen, Youxin and He, Shikun and Spee, Christine and Jin, Manlin and Ryan, Stephen J. and Hinton, David R. (2006) Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Experimental eye research 83 (1), pp. 212-222.

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Other URL: http://dx.doi.org/10.1016/j.exer.2005.12.007


Abstract

Retinal pigment epithelial (RPE) cells possess the potential to transdifferentiate into myofibroblasts after stimulation with transforming growth factor beta (TGFbeta) and are implicated in the pathogenesis of proliferative vitreoretinopathy. In this study we evaluated how TGFbeta2 and various extracellular matrix (ECM) proteins modulate the transdifferentiation of human fetal retinal pigment ...

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Item Type:Article
Date:July 2006
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Identification Number:
ValueType
10.1016/j.exer.2005.12.007DOI
16563380PubMed ID
Keywords:mesenchymal transdifferentiation; transforming growth factor; hepatocyte growth factor; extracellular matrix; fibronectin; alpha-smooth muscle actin
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:15 Mar 2007
Last Modified:13 Mar 2014 09:45
Item ID:1204
Owner Only: item control page

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