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Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists

URN to cite this document: urn:nbn:de:bvb:355-opus-11072

Igel, Patrick (2009) Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists. PhD, Universität Regensburg

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Abstract (English)

In previous studies NG-acylated imidazolylpropylguanidines, originally developed as histamine H2 receptor (H2R) agonists with reduced basicity relative to guanidine-type H2R agonists, turned out to be also highly potent at the histamine H3 receptor (H3R) and histamine H4 receptor (H4R). Particularly at the H4R, the compounds showed high agonistic efficacies. This thesis aimed at the design, ...

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Translation of the abstract (German)

In vorausgegangenen Untersuchungen wurden in einer Serie von NG-acylierten Imidazolylpropylguanidinen, die ursprünglich als Histamin H2 Rezeptor (H2R) Agonisten mit reduzierter Basizität ausgehend von H2R Agonisten des Guanidin-Typs entwickelten wurden, hochpotente Histamin H3 Rezeptor (H3R) und Histamin H4 Rezeptor (H4R) Liganden identifiziert. Diese Verbindungen zeigten insbesondere am H4R ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:15 January 2009
Referee:Prof. Dr. Armin Buschauer
Date of exam:15 December 2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Histaminrezeptor , Wirkstoff-Rezeptor-Bindung , H3-Rezeptor , Agonist , Guanidinderivate , Aralkylgruppe , Struktur-Aktivitäts-Beziehung , Histamin , H4-Rezeptor , H2-Rezeptor , Acylguanidin , Cyanoguanidin , Radioligand , H4-receptor , H2-receptor , acylguanidine , cyanoguanidine , radioligand
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:23
Last Modified:13 Mar 2014 12:26
Item ID:12093
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