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Ondansetron-analoge 5-HT3-Rezeptorliganden: Synthese, Stereochemie und in-vitro-Pharmakologie

URN to cite this document: urn:nbn:de:bvb:355-opus-9728

Jenning, Stefan (2009) Ondansetron-analoge 5-HT3-Rezeptorliganden: Synthese, Stereochemie und in-vitro-Pharmakologie. PhD, Universität Regensburg

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Abstract (German)

In der vorliegenden Arbeit wurden neue Ondansetron-analoge Tetrahydrocarbazolon- und Indol-Derivate synthetisiert und charakterisiert. Deren Wirkung auf den 5-HT3-Rezeptor wurde mittels eines in-vitro pharmakologischen Testmodells am Meerschweinchen-Ileum bestimmt. Durch Austausch des Imidazol-Rings von Ondansetron durch einen Piperidin-Ring wurde ein partieller Agonist erhalten. Durch die ...

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Translation of the abstract (English)

In this piece of work some new ondansetron derived tetrahydracarbazolone and indole derivates had been synthesized and characterized. The isolated longitudinal muscle of the guinea-pig with adhering plexus myentericus was used as a 5 HT3 receptor screening assay. Previous results in our group indicated that by replacing the imidazole ring of ondansetron with a piperidin ring a weak partial ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:18 June 2009
Referee:Sigurd (Prof. Dr.) Elz
Date of exam:9 May 2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Trennverfahren , Chemische Synthese , Tetrahydrocarbazole , Indolderivate , Analoga , Pharmakologie , Ligand <Biochemie> , Ondansetron , 5HT3 , Meerschweinchendarm , Enantiomere , Stereochemie , Tetrahydrocarbazolon , 5HT3 , guinea-pig ileum , enantiomers , stereochemistry , tetrahydrocarbazolone
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:25
Last Modified:13 Mar 2014 12:28
Item ID:12127
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