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Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie

URN to cite this document: urn:nbn:de:bvb:355-opus-10454

Prainer, Bianca-Cristine (2009) Tryptamin-Derivate als 5-HT4-Rezeptorliganden: Synthese und in-vitro-Pharmakologie. PhD, Universität Regensburg

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Abstract (German)

In der vorliegenden Arbeit wurden neue Derivate der Leitstruktur 5-Methoxytryptamin (2-(5-Methoxy-1H-indol-3-yl)ethanamin) hergestellt und mittels in-vitro pharmakologischer Testmodelle auf ihre Wirkung an Serotonin-Rezeptorsubtypen getestet. Die Leitverbindung 5-Methoxytryptamin wurde dabei durch Einführung verschiedener Substituenten in die Position 3 und 5 des Indolrings sowie an den ...

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Translation of the abstract (English)

In the present study new derivatives of the lead structure 5-methoxytryptamine have been synthesized and tested for their effect on 5-HT receptors using several pharmacological in-vitro assays. The parent compound 5-methoxytryptamine has been modified by the introduction of several substituents in the 3- and 5-position of the indole ring as well as at the indole nitrogen. The N-alpha-substituted ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:2 August 2009
Referee:Sigurd (Prof. Dr.) Elz
Date of exam:21 July 2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Tryptamin , Serotonin , Ligand <Biochemie> , Tryptaminderivate , Chemische Synthese , Pharmakologie , 5-HT4-Rezeptor , 5-HT2A-Rezeptor , M3-Rezeptor , Rattenösophagus , Rattenschwanzarterie , 5-HT4-receptor , 5-HT2A-receptor , M3-receptor , rat oesophagus , rat tail artery
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:25
Last Modified:13 Mar 2014 12:29
Item ID:12132
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