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Design, synthesis and structural evaluation of peptidomimetics towards foldamers, PNAs and non covalent inhibitors of the 20S proteasome

URN to cite this document: urn:nbn:de:bvb:355-opus-11127

Bordessa, Andrea (2009) Design, synthesis and structural evaluation of peptidomimetics towards foldamers, PNAs and non covalent inhibitors of the 20S proteasome. PhD, Universität Regensburg

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Abstract (English)

The first part of the project, which has been done at the university of Regensburg from November 2005 to October 2007, consisted in a stereoselective synthesis of sugar-like delta-amino acid. This amino acid was a suitable building block for the synthesis of an alpha-delta-pentapetide and an alpha-delta-heptapeptide containing a sequence of Phe and our building block. Conformational studies about ...

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Translation of the abstract (German)

Der erste Teil der Arbeit, welcher an der Universität Regensburg durchgeführt wurde (Nov. 2005 bis Okt. 2007), beschäftigte sich mit der stereoselektiven Synthese einer zucker-ähnlichen delta-Aminosäure. Diese Aminosäure stellt einen nützlichen Baustein für die Synthese von Oligopeptiden mit einer bestimmten Sekundärstruktur dar. Des weiteren wurde die o.g. Aminosäure in der Synthese von PNA ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:6 December 2009
Referee:Oliver (Prof. Dr.) Reiser
Date of exam:3 December 2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Peptidomimetikum , CD-Spektroskopie , Chirale Verbindungen , Proteasom , Inhibitor , Peptid-Nucleinsäuren , Proteinfaltung , PNA , Foldamere , Inhibitore , Proteasom , Peptidomimetika , peptidomimetic , foldamer , PNA , non covalent inhibitor , 20S proteasome
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:25
Last Modified:13 Mar 2014 12:29
Item ID:12138
Owner Only: item control page

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