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Design, synthesis and structural evaluation of peptidomimetics with a defined secondary structure

URN to cite this document: urn:nbn:de:bvb:355-opus-11050

Delatouche, Régis (2009) Design, synthesis and structural evaluation of peptidomimetics with a defined secondary structure. PhD, Universität Regensburg

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Abstract (English)

The synthesis of new delta-amino acids based on a gamma-butyrolactone ring was performed and they were inserted into various peptidomimetics for conformational studies. Some non-substituted and substituted butyrolactone building blocks were prepared by various methods. Then, homopeptides as well as mixed peptides were prepared and their secondary structures analysed by various techniques ...

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Translation of the abstract (German)

Durchgeführt wurde die Synthese von neuen, auf einen gamma-Butyrolaktonring basierenden, delta-Aminosäuren und deren Einbau in verschiedene Peptidomimetika für Konformationstudien. Einige unsubstituierte sowie funktionalisierte gamma-Butyrolakton Einheiten wurden dargestellt. Anschließend wurden Homo-Peptide und gemischte Peptide dargestellt und deren Sekundärstruktur durch verschiedene ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:6 December 2009
Referee:Oliver (Prof. Dr.) Reiser
Date of exam:3 December 2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Classification:
NotationType
92E99MSC
Keywords:Peptide , Peptidsynthese , Peptid-Bindung , Synthetische Peptide , Cyclopeptide , Piperazindion <2,5-> , Peptidomimetikum , Molekulardesign , , delta amino acid , diketopiperazine , peptidomimetics , unnatural amino acid , secondary structure , gamma butyrolactone
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2010 15:25
Last Modified:13 Mar 2014 12:29
Item ID:12139
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