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Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats

Tsui, Tung-Yu and Lau, Chi-Keung and Ma, Jian and Glockzin, Gabriel and Obed, Aiman and Schlitt, Hans-J. and Fan, Sheung-Tat (2006) Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. World journal of gastroenterology : WJG 12 (13), pp. 2016-2023.

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Other URL: http://www.wjgnet.com/1007-9327/12/2016.asp


Abstract

AIM: To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS: Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated. 1x 10(12) vg ...

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Item Type:Article
Date:7 April 2006
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
16610050PubMed ID
Keywords:Cirrhosis; Portal hypertension; Heme oxygenase; Gene therapy; Adeno-associated virus
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:30 Aug 2007
Last Modified:13 Mar 2014 09:46
Item ID:1214
Owner Only: item control page
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