Wild, Peter J. and Meyer, Stefanie and Bataille, Frauke and Woenckhaus, Matthias and Ameres, Markus and Vogt, Thomas and Landthaler, Michael and Pauer, Armin and Klinkhammer-Schalke, Monika and Hofstaedter, Ferdinand and Bosserhoff, Anja K. (2006) Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors. Archives of dermatology 142 (4), pp. 471-476.
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Other URL: http://dx.doi.org/10.1001/archderm.142.4.471
BACKGROUND: Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTAP) protein expression is associated with clinicopathologic variables in benign and malignant melanocytic skin tumors. OBSERVATIONS: Cytoplasmic MTAP expression was detected in 227 (72.1%) of 315 informative cases. Expression was significantly reduced in primary malignant melanomas and in melanoma metastases compared with benign nevi (P<.001 for both). No difference was noted in MTAP expression between primary malignant melanomas and melanoma metastases. In primary malignant melanomas, a Ki67-labeling index less than 5% was associated with MTAP expression (P = .04), suggesting that loss of MTAP expression is associated with proliferation. No other variables had significant associations with MTAP expression. Lymph node metastases demonstrated significantly higher MTAP expression compared with skin metastases (P = .01). In the overall cohort, MTAP expression was not associated with prognosis. Among 26 patients with MTAP-positive melanomas and tumor recurrence, 18 patients who received interferon therapy had a significant benefit compared with 8 patients who did not receive interferon therapy (P = .009). This was not seen in the patients with MTAP-negative tumors.Conclusion Methylthioadenosine phosphorylase protein expression may be a predictive marker of interferon therapy resistance in patients with melanoma and disease progression.
|Institutions:||Medicine > Lehrstuhl für Dermatologie und Venerologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||05 Mar 2007|
|Last Modified:||20 Jul 2011 20:52|