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DX5+ NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1

Hornung, Matthias and Farkas, Stefan A. and Sattler, Christine and Schlitt, Hans J. and Geissler, Edward K. (2006) DX5+ NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1. European journal of immunology 36 (5), pp. 1210-1221.

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Other URL: http://dx.doi.org/10.1002/eji.200535332


Abstract

NKT cells are activated by CD1d and show an immune regulating function. Here, we investigated whether DX5+ NKT cells could be used to reduce colitis in a chronic colitis mouse model and studied the potential immunological mechanisms involved. Chronic colitis was induced either by transfer of enriched CD62L+ CD4+ T cells to severe-combined-immunodeficient mice or by feeding dextran sodium sulfate ...

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Item Type:Article
Date:May 2006
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
10.1002/eji.200535332DOI
16619286PubMed ID
Keywords:CD1d; Cell transfer; Colitis; DX5⁺NKT cells; Programmed death ligand-1
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Ute Lange
Deposited On:02 Mar 2007
Last Modified:13 Mar 2014 09:46
Item ID:1220
Owner Only: item control page

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