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Morphometrie cerebraler Veränderungen und psychophysische Erfassung olfaktorischer Störungen bei Morbus Parkinson

URN to cite this document: urn:nbn:de:bvb:355-opus-12709

Herpers, Martin (2009) Morphometrie cerebraler Veränderungen und psychophysische Erfassung olfaktorischer Störungen bei Morbus Parkinson. PhD, Universität Regensburg

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Abstract (German)

Zur Evaluation eines neuen, fünfstufigen Segmentierungsansatzes (DARTEL)in der voxel-basierten Morphometrie wurden anatomische T1-gewichtete MR-Daten von 19 Patienten, 10 Männer und 9 Frauen, im Durchschnittsalter von 60 Jahre, und ebensovielen Kontrollen mit dem bisher in SPM5 etablierten, dreistufigen Segmentierungs-Algorithmus verglichen. Dabei konnte die Überlegenheit des neuen Verfahrens DARTEL gezeigt werden. Die untersuchten Patienten waren bis auf diejenigen mit tremordominantem Verlauf erst ein bis zwei Jahre erkrankt. Im Gegensatz zu bisherigen Arbeiten, die im fortgeschrittenen Erkrankungsverlauf Atrophien der anterioren olfaktorischen Nuclei (AON) und des anterioren Gyrus cinguli (BA 24&32) fanden sich in dem hier untersuchten Kollektiv volumetrisch nachweisbare Volumenvermehrungen in diesen Arealen, die sich auch anhand der bisher gebräuchlichen, dreistufigen Segmentierungsalgorithmen nachvollziehen ließen, ohne hierbei aber die Signifikanzschwelle zu überschreiten.

Translation of the abstract (English)

Using the new segmentation algorithm DARTEL for SPM8, which creates five different com¬partements of brain tissue from the MRI data set, a voxelbased morphometric analysis was performed, comparing 19 patients de novo or since less than 3 years suffering from Parkin¬sons disease with normal agematched controls. It could be shown, that the new algorithm is superior to the heretofore used solution, which gives only three different compartements. Surprising was the detection of a significant volume increase corresponding to the anterior olfactory nuclei (AON/BA11) and the anterior cingulate cortex (BA 24/32) in an early stage of the disease, where other authors describe some volume loss in the later course of the disease. Going back to the established segmentation algorithm with its three segments, these results could be reproduced by trend but not in the same dimension or level of significance. Patients with Parkinsons Disease are well known often to be olfactory disturbed before the manifestation of the disease itself. So all the subjects in the study underwent a differentiated psychophysiological testing with the sniffin stick test for olfactory threshold and discrimina¬tion ability. Thereby 42% of the patients were nearly anosmic, but on the other hand, there was a significant overlap with the controls, so that a discrimination between them couldn�t be carried out based on the performance in the psychophysiological testing. Taken as covariate in the voxelbased morphometry, the olfactory performance didn�t reveal new aspects in analysis.

Item Type:	Thesis of the University of Regensburg (PhD)
Referee:	Ulrich (Prof. Dr.) Bogdahn
Date of exam:	25 May 2009
Institutions:	Medicine > Lehrstuhl für Neurologie
Keywords:	Parkinson-Krankheit , Geruchsstörung , olfaktorische Störung , Morbus Parkinson , voxelbasierte Morphometrie , voxelbased morphometry , VBM , Parkisons disease
Subjects:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Owner:	Universitätsbibliothek Regensburg
Deposited On:	18 Jan 2010 14:53
Last Modified:	02 Oct 2012 08:50
Item ID:	12297

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