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Eignung von CYP1A2-Genvarianten als Prädiktoren des Serumspiegels von Olanzapin

URN to cite this document: urn:nbn:de:bvb:355-opus-13960

Wechsung, Vera (2009) Eignung von CYP1A2-Genvarianten als Prädiktoren des Serumspiegels von Olanzapin. PhD, Universität Regensburg.

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Abstract (German)

Das Enzym Cytochrom 1A2 spielt im Metabolismus verschiedener Medikamente eine zentrale Rolle. Es ist bekannt, dass durch Varianten seines Gens die Pharmakokinetik beeinflusst werden kann. In der vorliegenden Arbeit wurden in einer Stichprobe von Patienten mit der Diagnose Schizophrenie (ICD-10: F20.-) unter Medikation mit dem atypischen Neuroleptikum Olanzapin drei CytochromP450-1A2-Varianten ...


Translation of the abstract (English)

The enzyme cytochrome P450 1A2 plays an important role within the metabolism of various drugs. It is known that through variants of its gene pharmacokinetics can be influenced. Within the present paper three CYP1A2 variants were investigated in a sample of patients diagnozed with schizophrenia (ICD-10: F20.-) who were treated with the atypical antipsychotic Olanzapine. For the determination of ...


Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:17 November 2009
Referee:Göran (Prof. Dr.) Hajak
Date of exam:14 October 2009
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Keywords:Molekulargenetik , Olanzapin , Cytochrom P-450 , Cytochrome , Schizophrenie , , gene variants , Olanzapine , CYP450 1A2
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:18 Jan 2010 14:11
Last Modified:13 Mar 2014 12:40
Item ID:12364
Owner Only: item control page


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