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Genetic analyses of fibronectin functions in vivo and in vitro

URN to cite this document: urn:nbn:de:bvb:355-opus-14140

Leiß, Michael (2009) Genetic analyses of fibronectin functions in vivo and in vitro. PhD, Universität Regensburg

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Abstract (English)

Fibronectin (FN), a major adhesive glycoprotein ubiquitously present in the extracellular matrix and in blood plasma of vertebrates, is secreted by cells as a disulfide-bonded dimer. FN requires cell surface expressed integrins to assemble into a functional fibrillar network, which in turn orchestrates the assembly of other ECM components to promote cell adhesion, cell migration and a large ...


Translation of the abstract (German)

Fibronektin (FN) ist ein in Wirbeltieren fast ubiquitär vorkommendes, adhäsives Glykoprotein der Extrazellulären Matrix und des Blutplasmas. FN wird von Zellen als Disulfid-verbrücktes Dimer sezerniert, welches erst durch die Interaktion mit Integrin-Zelloberflächenrezeptoren zu einem funktionalen faserigen FN-Netzwerk zusammengesetzt wird. Dieses Netzwerk beeinflusst nicht nur Prozesse wie ...


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Item Type:Thesis of the University of Regensburg (PhD)
Date:17 December 2009
Referee:apl. Prof. Dr. Rainer Deutzmann
Date of exam:26 October 2009
Additional Information (public):J Cell Biol 178(1): 167-178
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Rainer Deutzmann
Keywords:Fibronectin , Extrazelluläre Matrix , Assembly , RGD-Sequenz , Genmutation , Embryonalentwicklung , Integrin , pFN , cFN , integrin , fibers , fibrillar matrix , module , disulfide bond
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:18 Jan 2010 14:21
Last Modified:13 Mar 2014 12:40
Item ID:12379
Owner Only: item control page


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