Brost, S and Wenzel, J J and Ganten, T M and Filser, M and Flechtenmacher, C and Boehm, S and Astani, A and Jilg, W and Zeier, M and Schnitzler, P (2010) Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 47 (1), pp. 89-92.
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Hepatitis E infection is usually a self-limiting disease and an important cause of acute hepatitis in tropical and subtropical regions where the virus is endemic. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described and the number of documented autochthonous infections seems to be increasing. We report three sporadic cases of autochthonous hepatitis E infections in Southwestern Germany which presented at our university hospital within two years. All cases were men who presented with acute hepatitis, icterus and elevated liver. In case 1 and case 2, liver biopsy revealed acute hepatitis, both patients were positive for anti-HEV antibodies, case 1 was also positive for HEV RNA with a viral load of 3.0x10(3)copies/ml in serum. In case 3, anti-HEV antibodies were detectable and HEV RNA was detected in serum (4.3x10(3)copies/ml) and stool (1.4x10(6)copies/ml). None of the patients had a recent travel history outside Germany and close contact to animals has been denied. HEV sequence analysis of two patients revealed genotype 3 with homologies to other European isolates and isolates from swine. Thus the source of infection remains unclear. Hepatitis E should be considered in differential diagnosis in patients with unexplained hepatitis and patients with acute hepatitis, whatever their age or travel history might be, should be tested for HEV.
|Institutions:||Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene|
|Keywords:||Hepatitis E virus; HEV; Acute hepatitis, Autochthonous hepatitis E|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
500 Science > 500 Natural sciences & mathematics
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Owner:||Dr. Jürgen Wenzel|
|Deposited On:||09 Feb 2010 07:08|
|Last Modified:||20 Jul 2011 22:19|