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Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1

Calzada, Maria J. and Annis, Douglas S. and Zeng, Bixi and Marcinkiewicz, Cezary and Banas, Bernhard and Lawler, Jack and Mosher, Deane F. and Roberts, David D. (2004) Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1. The Journal of biological chemistry 279 (40), pp. 41734-41743.

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Other URL: http://dx.doi.org/10.1074/jbc.M406267200


Abstract

In addition to the three known beta(1) integrin recognition sites in the N-module of thrombospondin-1 (TSP1), we found that beta(1) integrins mediate cell adhesion to the type 1 and type 2 repeats. The type 1 repeats of TSP1 differ from typical integrin ligands in that recognition is pan-beta(1)-specific. Adhesion of cells that express one dominant beta(1) integrin on immobilized type 1 repeats ...

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Item Type:Article
Date:1 October 2004
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1074/jbc.M406267200DOI
15292271PubMed ID
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:15 Mar 2007
Last Modified:13 Mar 2014 09:49
Item ID:1289
Owner Only: item control page

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