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TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells

Rodríguez-Barbero, A. and Dorado, F. and Velasco, S. and Pandiella, A. and Banas, B. and López-Novoa, J. M. (2006) TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells. Kidney international 70 (5), pp. 901-909.

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Other URL: http://dx.doi.org/10.1038/sj.ki.5001626


Abstract

Transforming growth factor-beta1 (TGF-beta1) plays a fundamental role in the progression of renal diseases. Accumulating evidence has suggested that eicosanoids derived from cyclooxygenase-2 (COX-2) participate in a number of pathological processes in immune-mediated renal diseases. Mesangial cells (MC) play a major role in physiological and pathophysiological renal processes. MC express ...

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Item Type:Article
Date:September 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1038/sj.ki.5001626DOI
16820791PubMed ID
Keywords:transforming growth factor-1; cyclooxygenase; prostaglandin-E2; mesangial cells; mitogen-activated protein kinase; phosphatidylinositol 3 kinase
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:22 Mar 2007
Last Modified:13 Mar 2014 09:50
Item ID:1315
Owner Only: item control page

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