Hoffmann, Ute and Banas, Bernhard and Krüger, Bernd and Banas, Miriam and Bergler, Tobias and Böger, Carsten and Kammerl, Martin and Obed, Aiman and Rümmele, Petra and Segerer, Stephan and Riegger, Günter A. J. and Krämer, Bernhard K. (2006) SDF-1 expression is elevated in chronic human renal allograft rejection. Clinical transplantation 20 (6), pp. 712-718.
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The exact mechanism of acute and chronic allograft rejection still remains unclear. The chemokine SDF-1 as mediator of allograft rejection has been under intensive investigation in liver, cardiac and bone marrow transplantation, whereas in renal transplantation, there are no reports about SDF-1 to date. This study was performed to evaluate if SDF-1 might also play an important role in human renal graft biopsies. One hundred and ninety formalin-fixed, paraffin-embedded renal allograft biopsies were included in the analysis from patients with normal renal graft morphology (according to Banff 97 classification grade 1, n = 84), with acute interstitial rejection (Banff grade 4 type I, n = 10), with acute vascular rejection (Banff grade 4 type II, n = 21), with chronic allograft nephropathy (CAN, Banff grade 5, n = 23), and without rejection but with various other lesions (Banff grade 6, n = 42). SDF-1 was localized by immunohistochemistry. In biopsies with CAN, SDF-1 expression was significantly elevated in interstitial infiltrates and infiltrating neointimal cells of arteries compared with biopsies with normal renal graft morphology. This is the first study describing a role of SDF-1 in human renal allograft rejection. We were able to demonstrate in a large number of biopsies an upregulation of SDF-1 in patients with CAN. Whether SDF-1 has pro-inflammatory or protective properties in this setting has to be evaluated in further trials.
|Institutions:||Medicine > Lehrstuhl für Innere Medizin II|
|Keywords:||human renal allograft rejection; immunohistochemistry; SDF-1|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||22 Mar 2007|
|Last Modified:||20 Jul 2011 20:54|