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Regulation kardialer K+-Kanäle und deren Blockade im Modell der tachykardie-induzierten Herzinsuffizienz

URN to cite this document: urn:nbn:de:bvb:355-epub-134202

Husser, Oliver (2010) Regulation kardialer K+-Kanäle und deren Blockade im Modell der tachykardie-induzierten Herzinsuffizienz. PhD, Universität Regensburg

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Abstract (German)

Ziel der Arbeit war es, im Modell der tachykardie-induzierten Herzinsuffizienz am Kaninchen, die Kalium Kanal-Expression, sowie das Sicherheitsprofil eines vorhofselektiven Antiarrhythmikums (AVE0118) zu testen. Bei experimenteller Herzinsuffizienz mittels tachykarder Stimulation kommt es zusammen mit der Funktionseinschränkung zur biatrialen und biventrikulären Dilatation und ...

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Translation of the abstract (English)

Congestive heart failure (CHF) is often associated with atrial fibrillation. The safety of many antiarrhythmic drugs in CHF is limited by proarrhythmic effects. We aimed to assess the safety of a novel atrial-selective K+-channel blocker AVE0118 in CHF compared to a selective (dofetilide) and a non-selective IKr blocker (terfenadine). For the induction of CHF, rabbits (n=12) underwent rapid right ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:11 October 2010
Referee:Prof. Dr. Andreas Luchner
Date of exam:14 July 2009
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Research groups and research centres:Not selected
Keywords:Herzinsuffizienz, Kalium Kanäle, AVE0118, Gen Expression, Antiarrhythmika, congestive heart failure, Potassium channels, AVE0118, gene expression, antiarrhythmic drugs
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:11 Oct 2010 13:41
Last Modified:13 Mar 2014 13:56
Item ID:13420
Owner Only: item control page
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