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Molecular mechanisms of nucleosome positioning and DNA methylation in chromatin

URN to cite this document: urn:nbn:de:bvb:355-epub-134301

Schrader, Anna (2010) Molecular mechanisms of nucleosome positioning and DNA methylation in chromatin. PhD, Universität Regensburg

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Abstract (English)

In the eukaryotic cell nucleus DNA needs to be highly condensed. The initial level of DNA compaction is mediated by the wrapping of DNA around histone octamers to form nucleosomes. For efficient DNA metabolism, including DNA replication, transcription, repair and recombination, access to the required sequences must be granted. Hence, nucleosomes need to be highly dynamic. This is mediated by ...

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Translation of the abstract (German)

Im eukaryotischen Zellkern liegt die DNA in stark kondensierter Form vor. Die erste Ebene der Chromatin-Kompaktierung wird durch die Windung der DNA um ein Histonoktamer erreicht, wobei ein sogenanntes Nukleosom gebildet wird. Zur Gewährleistung eines effizienten DNA-Metabolismus, wie DNA-Replikation, -Transkription, -Reparatur und -Rekombination müssen die entsprechenden Sequenzen zugänglich ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:3 December 2010
Referee:Prof. Dr. Gernot Längst
Date of exam:8 October 2009
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Research groups and research centres:Not selected
Keywords:Chromatin, Methylierung, Nucleosom, Positionierung, DNS-Krümmung, DNS-Methyltransferase, DNS, Chromatin Remodeling Komplex, chromatin remodeling complex
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:03 Dec 2010 14:52
Last Modified:13 Mar 2014 14:09
Item ID:13430
Owner Only: item control page

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