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The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes

Suleiman, Hani and Heudobler, Daniel and Raschta, Anne-Sarah and Zhao, Yangu and Zhao, Qi and Hertting, Irmgard and Vitzthum, Helga and Moeller, Marcus J. and Holzman, Lawrence B. and Rachel, Reinhard and Johnson, Randy and Westphal, Heiner and Rascle, Anne and Witzgall, Ralph (2007) The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Developmental biology 304 (2), pp. 701-712.

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Abstract

Patients with nail-patella syndrome, which among other symptoms also includes podocyte-associated renal failure, suffer from mutations in the LMX1B gene. The disease severity among patients is quite variable and has given rise to speculations on the presence of modifier genes. Promising candidates for modifier proteins are the proteins interacting with LMX1B, such as LDB1 and E47. Since human ...

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Item Type:Article
Date:2007
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Michael Thomm
Identification Number:
ValueType
17316599PubMed ID
10.1016/j.ydbio.2007.01.020DOI
Classification:
NotationType
AnimalsMESH
Basic Helix-Loop-Helix Transcription Factors/metabolismMESH
DNA-Binding Proteins/metabolismMESH
Disease Models, AnimalMESH
Gene Expression Regulation, DevelopmentalMESH
Homeodomain Proteins/metabolismMESH
HumansMESH
Kidney Failure/metabolismMESH
MaleMESH
MiceMESH
Mice, KnockoutMESH
Nail-Patella Syndrome/pathologyMESH
Nephrons/pathologyMESH
Podocytes/physiologyMESH
RatsMESH
Transcription Factors/metabolismMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:22 Mar 2010 08:11
Last Modified:22 Mar 2010 08:11
Item ID:13640
Owner Only: item control page
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