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Layer-by-layer assembled gold nanoparticles for siRNA delivery

Elbakry, Asmaa and Zaky, Alaa and Liebl, Renate and Rachel, Reinhard and Goepferich, Achim and Breunig, Miriam (2009) Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano letters 9 (5), pp. 2059-2064.

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Abstract

Although uptake into cells is highly complex and regulated, heterogeneous particle collectives are usually employed to deliver small interfering RNA (siRNA) to cells. Within these collectives, it is difficult to accurately identify the active species, and a decrease in efficacy is inherent to such preparations. Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of ...

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Item Type:Article
Date:2009
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Michael Thomm
Identification Number:
ValueType
19331425PubMed ID
10.1021/nl9003865DOI
Classification:
NotationType
AnimalsMESH
CHO CellsMESH
CricetinaeMESH
CricetulusMESH
Gold/chemistryMESH
Green Fluorescent Proteins/geneticsMESH
Metal Nanoparticles/chemistryMESH
RNA, Small Interfering/metabolismMESH
TransfectionMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:24 Mar 2010 10:30
Last Modified:24 Mar 2010 10:30
Item ID:13687
Owner Only: item control page
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