Elbakry, Asmaa and Zaky, Alaa and Liebl, Renate and Rachel, Reinhard and Goepferich, Achim and Breunig, Miriam (2009) Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano letters 9 (5), pp. 2059-2064.
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Although uptake into cells is highly complex and regulated, heterogeneous particle collectives are usually employed to deliver small interfering RNA (siRNA) to cells. Within these collectives, it is difficult to accurately identify the active species, and a decrease in efficacy is inherent to such preparations. Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of siRNA on gold in a layer-by-layer approach, and we further report on the cellular delivery and siRNA activity as functions of surface properties.
|Institutions:||Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Michael Thomm|
|Subjects:||500 Science > 570 Life sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||24 Mar 2010 10:30|
|Last Modified:||24 Mar 2010 10:30|