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Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis

URN to cite this document: urn:nbn:de:bvb:355-epub-140850

Spangler, Corinna (2010) Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis. PhD, Universität Regensburg

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Abstract (English)

The adenylyl cyclase (AC) toxins EF and CyaA contribute to the pathogenity and mortality of anthrax and whooping cough caused by Bacillus anthracis and Bordetella pertussis, respectively. Inhibitors of bacterial toxins would mitigate the course of disease and increase survival rates. A luminescence-based AC assay was developed as screening tool for AC toxin inhibitors. The assay prooved to be ...

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Translation of the abstract (German)

Die Adenylyl-Zyklase-(AC)-Toxine EF und CyaA tragen zur Pathogenität und Mortalität von Anthrax und Keuchhusten bei. Inhibitoren, die auf bakterielle Toxinen wirken, würden deshalb den Verlauf der Krankheit mildern und die Überlebenschancen erhöhen können. Ein lumineszenzbasierter AC-Assay wurde für das Screening von Inhibitoren für AC-Toxine entwickelt. Der Assay hat sich als schnell und ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:26 July 2010
Referee:Prof. Dr. Roland Seifert and Prof. Dr. Otto Wolfbeis
Date of exam:11 June 2010
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Research groups and research centres:Not selected
Keywords:adenylyl cyclases, toxins, edema factor, Bacillus anthracis, Bordetella pertussis, cyclic nucleotides
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jul 2010 10:19
Last Modified:13 Mar 2014 13:43
Item ID:14085
Owner Only: item control page
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