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Destruction of human solid tumors by alkyl lysophospholipids

Runge, M. H. and Andreesen, Reinhard and Pfleiderer, A. and Munder, P. G. (1980) Destruction of human solid tumors by alkyl lysophospholipids. Journal of the National Cancer Institute 64 (6), pp. 1301-6.

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Abstract

Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a highly significant retardation of the in vivo growing human tumors. Neither oral nor iv administration of these compounds caused any recognizable side effects.

Item Type:

Article

Institutions:

Medicine > Abteilung für Hämatologie und Internistische Onkologie

Identification Number:

Value	Type
6929370	PubMed ID

Classification:

Notation	Type
Adenocarcinoma/drug therapy	MESH
Animals	MESH
Carcinoma/drug therapy	MESH
Female	MESH
Genital Neoplasms, Female/drug therapy	MESH
Humans	MESH
Lysophosphatidylcholines/therapeutic use	MESH
Lysophospholipids	MESH
Mice	MESH
Mice, Nude	MESH
Neoplasm Transplantation	MESH
Neoplasms, Experimental/drug therapy	MESH
Ovarian Neoplasms/drug therapy	MESH
Phospholipids/therapeutic use	MESH
Sarcoma/drug therapy	MESH
Teratoma/drug therapy	MESH
Transplantation, Heterologous	MESH
Uterine Cervical Neoplasms/drug therapy	MESH
Uterine Neoplasms/drug therapy	MESH