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Clonogenicity of normal and malignant hematopoietic progenitor cells after exposure to synthetic alkyl-lymphospholipids

Dulisch, I. and Neumann, H. A. and Löhr, G. W. and Andreesen, Reinhard (1985) Clonogenicity of normal and malignant hematopoietic progenitor cells after exposure to synthetic alkyl-lymphospholipids. Blut 51 (6), pp. 393-9.

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Abstract

Alkyl-lysophospholipids (ALP) are synthetic analogues of natural lysophosphatidylcholine and represent a new class of anti-tumor agents. They are cytotoxic in vitro with a high selectivity for neoplastic cells which, in contrast to normal cells, lack an alkyl-cleavage enzyme to degrade the adsorbed ALP molecules. As ALP accumulates, it interferes with normal membrane phospholipid turnover and ...

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Item Type:Article
Date:1985
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
3865693PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/therapeutic useMESH
Cell LineMESH
Dose-Response Relationship, DrugMESH
Hematopoiesis/drug effectsMESH
Hematopoietic Stem Cells/physiologyMESH
HumansMESH
Leukemia, Myeloid, Acute/physiopathologyMESH
Lysophosphatidylcholines/therapeutic useMESH
LysophospholipidsMESH
MiceMESH
Phospholipid EthersMESH
Phospholipids/therapeutic useMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:13 Apr 2010 05:04
Last Modified:13 Apr 2010 05:04
Item ID:14199
Owner Only: item control page
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